Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
ECM treatments, which are currently gaining attention, are a form of cosmetic medicine designed to improve skin quality by enhancing firmness, elasticity, and hydration. Yayoi Clinic offers three types of ECM treatments, each with different ingredients and approaches tailored to specific skin concerns. In this article, we’ll explain the features and pricing of these three treatments. Be sure to read on to the end.
Let's Check the Effectiveness of ECM Formulations

ECM (extracellular matrix) formulations are medications that act on the ECM to improve the skin’s elasticity and refine its texture. The ECM (extracellular matrix) is,Non-cellular tissue that fills the spaces between cells, such as collagen and elastinです。ECM製剤はコラーゲンやエラスチンなどの生成を促し、肌の土台である真皮の弾力性を高めます。
ECM製剤はPN製剤やPDLLA製剤と同じ肌育治療に分類されることがありますが、アプローチする仕組みが異なります。
Yayoi Clinic offers three ECM products!

ヤヨイクリニックでは、3種類のECM製剤を取り扱っています。
〈スネコス〉
主成分:非架橋ヒアルロン酸、6種類のアミノ酸
特徴:さらさらした質感で、A natural finish even on areas with thin skinになる
〈プロファイロ〉
主成分:2種類の分子量が異なるヒアルロン酸
特徴:It can reach down to the fat layer beneath the dermis,、ふっくらと弾力アップできる
〈ハイドロ〉
主成分:3種類の分子量が異なるヒアルロン酸
特徴:3種類のヒアルロン酸がハイブリッドされているため、It possesses strong cell-activating and cell-regenerating properties
How to Choose the Right ECM Formulation

次に、3つのECM製剤の使い分け方を紹介します。
〈スネコス〉
小ジワなどの部分的なお悩みにおすすめ!
- Horizontal wrinkles on the forehead
- Neck wrinkles
- Fine lines around the eyes
- Dark circles under the eyes
〈プロファイロ〉
ふっくらハリ感が欲しい方におすすめ!
- laugh lines
- wrinkle
- Cheek Hollows
- slack
〈ハイドロ〉
シワのケアやリフトアップを目指したい方におすすめ!
- Wrinkles around the eyes and mouth
- Neck wrinkles
- Stretch Marks
Please also refer to the comparison table below.
| Formulation | main ingredient | Common Concerns |
| SUNEKOS®. | Uncrosslinked HA + Amino Acids | fine wrinkles |
| Profhilo (PROFHILO®︎) | Hybrid HA | Firmness and Sagging |
| Hydro Injections | 3 Types of HA | Wrinkles & Moisturizing |
Check the prices of ECM formulations
最後に、ヤヨイクリニックで提供しているECM製剤の料金を紹介します。
〈スネコス〉
Around the eyes 3 times
通常価格:131,800円(税込)
4 sessions for the entire face
通常価格:175,780円(税込)
〈プロファイロ〉
顔or首2回
通常価格:158,400円(税込)
〈ハイドロ〉
one's whole face
通常価格:77,000円(税込)全顔+首
通常価格:130,900円(税込)
ECM製剤は、製剤ごとに特徴や料金、向いているお悩みが異なります。比較しながら、自分の肌状態や理想の仕上がりに合った方法を選びましょう。
For ECM formulations, visit YAYOI CLINIC
ECM製剤は、肌のハリや弾力、うるおいなど、年齢とともに気になりやすい肌悩みにアプローチする肌育治療です。それぞれの製剤で特徴や向いているお悩みが異なるため、ご自身の肌状態や理想の仕上がりに合わせて選ぶことが大切です。
ヤヨイクリニックでは、スネコス・プロファイロ・ハイドロの3種類をご用意し、一人ひとりのお悩みに合わせてご提案しています。どのECM製剤が自分に合うか迷っている方も、お気軽にご相談ください。
広島の美容皮膚科・美容内科・美容外科・アートメイク YAYOI CLINICでは、お肌、お体、お顔のお悩み別に治療法をご紹介しています。
お客さまにより良い選択肢をご提案できますよう一人ひとりのお肌の状態を見極め、治療期間やご予算、ダウンタイムの許容範囲などご希望に合わせた治療方針を立案していく考えです。
お悩みのある方は、まずはカウンセリングにお越しください。
【施術の内容】スネコス
【施術回数の目安】2週間に1回×3~4回(1クール)※治療内容によっても異なります。
【費用】¥128,000〜¥175,800※部位・回数によって料金は異なります。
【副作用・リスク】出血、赤み、腫れ、圧痛、疼痛、痒み、軽度/中程度のアザ、軽度の浮腫、内出血など
【使用機器について】
Snekos treatment includes the use of unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-The special ratio of amino acids in the drug has been patented internationally by an Italian development company.
-CE Mark Class III (European safety standard conformity approval)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】プロファイロ
【施術回数の目安】
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
【費用】¥82,000~¥158,400※回数によって料金は異なります。
【副作用・リスク】注入部位の痛み、炎症、赤み、かゆみ、腫れ、内出血、体質によるアレルギー反応など
【使用機器について】
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】ハイドロ
【施術回数の目安】2週間ごとに3~4回
【費用】¥71,000~204,000円※部位・回数によって料金は異なります。
【副作用・リスク】
Tingling, itching, redness, and heat may occur for about 2 days after treatment.
Swelling may remain for 1-2 days and internal bleeding for about 7 days, but usually resolves spontaneously.
Depending on the individual and the injection site, the puffiness may remain for 1-3 days after treatment. It will settle naturally as the drug is diffused.
【使用機器について】
Hydro treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Obtained European CE Mark[p1].
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.

