Dr. Yayoko Ito
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Graduated from Hiroshima University School of Medicine. After working in the Department of General Medicine, he studied under doctors at the forefront of cosmetic medicine. After acquiring knowledge and skills in aesthetics, he became the director of YAYOI CLINIC in 2023. Her specialties include Botox, hyaluronic acid injections, and customized sagging treatment. His motto is to provide natural and pain-free treatments with careful consultation.
Are you considering getting a manual Rejuran (polynucleotide) injection treatment in Hiroshima? Rejuran treatments can be administered either manually—where a doctor injects the solution directly—or using specialized equipment, and each method offers different benefits. In this article, YAYOI CLINIC, a cosmetic dermatology clinic in Hiroshima, explains the characteristics of manual Rejuran treatments and offers tips to help alleviate any concerns you may have. If you’re hoping to achieve clear, healthy skin with Rejuran, we encourage you to read on.
リジュラン手打ちを受ける前に知っておきたいQ&A｜広島ヤヨイクリニック
For those who are concerned—asking questions like, “Does the injection hurt?” or “I’d like to try Rejuran administered by hand, but how effective is it?”—Hiroshima Yayoi Clinic answers these common questions.
■ How much does it hurt during the procedure? Is anesthesia available?
Since the Rejuran manual injection procedure uses ultra-fine needles to inject the solution little by little,It is accompanied by a prickling sensation.. If you'd like to undergo treatment with minimal discomfort, pleaseApplying a topical anesthetic (anesthetic cream) can help alleviate discomfort.I am sure you will.
広島ヤヨイクリニックのリジュラン手打ち施術は、痛みに配慮された薬剤を使用します。麻酔も使用可能なので痛みが心配な方は、カウンセリングでお気軽にご相談ください。
■How many sessions are needed to see results?
Some people notice improved skin firmness and hydration after just one Rejuran treatment. However, to fully bring out the treatment’s benefits, it is recommended to undergo multiple sessions over time. Results may vary depending on individual skin conditions, butGenerally speaking, undergoing a total of 3 to 4 treatments at a rate of once every 2 to 3 weeks tends to help improve the skin's condition.I am sure you will.
その後は数ヶ月に1回程度のメンテナンスを続けることで、健やかな肌状態を維持しやすくなります。肌の状態や年齢によって適切な回数や頻度は異なるため、まずは担当医師と長期的なスケジュールを相談しましょう。
■ Can I wear makeup or take a bath on the day of the procedure?
After the procedure, swelling may occur at the injection site. This usually subsides within a few hours to about one day, but since we need to monitor the situation,Please avoid wearing makeup for 12 hours after your treatment.. You can start wearing makeup again the next day.You may bathe and wash your face starting on the day of the procedure, but please be careful not to scrub the treated area too vigorously.Please note that swelling, redness, and bruising may occur for a few days. Also, since your skin will be sensitive after the procedure, be sure to moisturize thoroughly and protect your skin from UV rays.
■What's the difference between Rejuran and the HydraFacial?
Hiroshima Yayoi Clinic explains the difference between Rejuran and hydrafacial treatments—two options people often struggle to choose between when looking to improve skin firmness and radiance. Hydrafacial treatments primarily use a specialized stamp-type device,Delivers beauty ingredients evenly to the skin, providing overall hydration and radianceThis is a treatment. On the other hand, Rejuran delivers polynucleotides derived from salmon to support the skin’s natural functions, addressing firmness and elasticity from the foundation up. If you’re looking for an overall glow, the HydraFacial is the better choice; if you’re seeking fundamental skin health and fine line care, Rejuran is the better option.
■What is the difference between Rejuran and hyaluronic acid injections?
Hyaluronic acid isWith just one injection, it can lift facial features, add volume, and—thanks to its ability to temporarily retain moisture—create a noticeable transformation.施術です。一方でリジュランは、肌がもともと持つ働きをサポートするため、自然な形で肌のハリ感や弾力にアプローチできます。シワや小ジワケアにも向いており、お手入れした感が少ない仕上がりが期待できます。
▼【リジュラン】広島ヤヨイクリニックの施術の特徴と料金表を確認する
To Avoid Regrets! How to Choose a Clinic for Hand-Administered Rejuran in Hiroshima
With manual injections, the doctor’s skill in making precise adjustments to the injection volume and depth affects the final results. In the following section, Hiroshima Yayoi Clinic explains how to choose a clinic that will ensure you’re satisfied with your Rejuran treatment—so you won’t have any regrets.
■Does the clinic have a team of trusted doctors with extensive clinical experience?
The manual administration of Rejuran is a delicate procedure in which the injection angle and volume are controlled for each individual injection based on the patient’s facial bone structure and skin thickness. For this reason, the treating physician’s level of experience and number of cases treated are key factors in the decision-making process.Check photos of actual cases posted on the official website and social media to see the beautiful results and review the doctor’s background.Let's do it. It's also helpful to consider whether the doctor is board-certified and whether they specialize in injection treatments on a regular basis.
■ Is the pricing structure clear? Compare based on the total cost
Since multiple, ongoing treatments are recommended for Rejuran, it’s important to consider not only the cost per session but alsoIt's important to figure out how much it will cost in total.です。例えば「広島でリジュランが安い美容医療」と検索した場合でも、トータル価格で高額になる可能性がある点に注意しましょう。
薬剤そのものの代金に加え、初診料、再診料、表面麻酔代、極細針への変更オプション代などが別途発生するクリニックもあります。カウンセリングの段階で、必要な備品を含めた総額の見積もりを提示してくれるか確認しましょう。
■Can I discuss my concerns in depth during counseling?
To ensure you feel confident about undergoing treatment, pay close attention to the quality of the initial consultation. Look for a clinic where doctors carefully examine each patient’s skin condition. Don’t just focus on the benefits, but also—Make sure they thoroughly explain the risks associated with the procedure and the downtime period.Please do so. Another important point is whether they show a willingness to answer questions sincerely.
■Is the location convenient enough to make it easy to keep coming here?
Healthy skin doesn’t happen overnight, and if you want to truly feel the effects of your treatments, regular visits to the clinic are key. Choosing a clinic that’s conveniently located near your home or workplace will make your visits less of a burden and lower the barrier to getting treatment.
What Exactly Is Rejuran? An Injection Treatment for Healthy Skin
In the following section, we’ll explain the characteristics of Rejuran’s basic ingredients and the differences between the various injection methods.
■Effects of "Polynucleotide (PN)," the Main Ingredient in Rejuran
Rejuran is a South Korean-developed drug whose main ingredient is a polynucleotide (PN) derived from salmon DNA. Polynucleotides are,It is expected to bring out the skin's natural health, and the injections are designed to improve skin quality.. This treatment is ideal for those looking to improve skin firmness and reduce wrinkles.
■ A Doctor’s Skill Matters! The Differences and Benefits of “Manual” vs. “Machine” Procedures
There are two methods for administering Rejuran: manual injection, in which a doctor administers the injection using a syringe, and automated injection, which uses a specialized device. The characteristics of each method are summarized in the table below. Manual injection of Rejuran is,Doctors can focus treatment on specific areas while monitoring the patient's skin condition.So, consider this option when you want to focus on caring for specific, small areas.
| Handmade | Machine-printed | |
| feature | Examine the condition of each area and treat specific areas, such as fine lines | Enables broad, fast, and uniform treatment |
| demerit | People who are more prone to pain compared to those who use a typewriter | It is difficult to perform precise treatments on specific areas, such as fine wrinkles around the eyes. |
| Suitable for. | For those who want to target and effectively treat fine lines, dark circles, acne scars, and other specific concerns | For those looking to improve the overall texture of their skin—such as by enhancing firmness and refining the skin's texture— |
■ Characteristics of Different Types of Rejuran and Their Recommended Application Sites
リジュランには、お悩みの部位に合わせていくつかのシリーズが展開されています。顔全体のベースケアには標準的な「リジュラン（ヒーラー）」、皮膚が薄くデリケートな目元や小ジワには粘度が低い「リジュランi（アイ）」、クレーターや固くなった傷痕のケアには高粘度の「リジュランS」が用いられます。
広島ヤヨイクリニックでは、このうち目元など皮膚の薄い部位への注入に適したリジュランi（リジュランアイ）を使用しています。期待できる効果は以下のとおりです。
| part | Expected Benefits |
| Outer corners of the eyes and the area around the eyes | Care for Wrinkles and Fine Lines |
| Thinning skin around the eyes | Improved Firmness |
| Dark Circles and Dullness Under the Eyes | Refine skin texture, brighten skin tone |
■If you're considering a Rejuran manual treatment in Hiroshima, schedule a consultation to discuss your options.
リジュランの手打ち施術を広島で検討されている方へ、期待できる効果やクリニック選びのポイントをお伝えしました。手打ちはデリケートな目の下や小ジワへピンポイントにアプローチできる点が魅力です。痛みが不安な方も事前の表面麻酔や冷却などの工夫で負担を抑えて受けられます。まずはクリニックのカウンセリングで悩みを相談してみませんか。
広島の美容皮膚科・美容内科・美容外科・アートメイク ヤヨイクリニック（YAYOI CLINIC）では、お肌、お体、お顔のお悩み別に治療法をご紹介しています。
皆さまにより良い選択肢をご提案できますよう一人ひとりのお肌の状態を見極め、治療期間やご予算、ダウンタイムの許容範囲などご希望に合わせた治療方針を立案していく考えです。
お悩みのある方は、まずはカウンセリングにお越しください。
■Related Articles Recommended for You
【施術の内容】リジュラン
【施術回数の目安】2〜3週間ごとに計3～4回/メンテナンスとして、半年に1回を推奨。
【費用】¥58,000〜¥204,000※部位・回数によって料金は異なります。
【副作用・リスク】疼痛・赤み・腫れ・内出血
【使用機器について】
Rejuran treatments include procedures using unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
