Kiko Kono, M.D.
Profile
Graduated from Kawasaki Medical School. Worked as a dermatologist for about 20 years at core hospitals. After many years of experience and achievements, he became a cosmetic dermatologist. His practice style is to examine the skin thoroughly and pursue what is happening where on the skin and approach the problem. Her specialties include customized treatment, laser treatment, Botox, and skin growth injections. In her private life, she is a mother of two children.
Do you know the difference between non-cross-linked hyaluronic acid and cross-linked hyaluronic acid? In fact, different formulations of hyaluronic acid are suitable for different areas and have different effects. Learn more about the formulations and procedures to find the hyaluronic acid injections that best suit your concerns.
What is the difference between cross-linked hyaluronic acid and non-cross-linked hyaluronic acid?

There are two types of hyaluronic acid, "cross-linked" and "non-cross-linked," and there are differences in suitable areas and procedures. Cross-linking is a process used to link hyaluronic acid together. Let's take a look at the characteristics of each.
■ Cross-linked hyaluronic acid
Cross-linked hyaluronic acid is hard and is not easily degraded by the body,Suitable for increasing volume。
Non-cross-linked hyaluronic acid
Non-cross-linked hyaluronic acid is soft, spreadable, and easily blended,Effective in retaining skin moisture and improving skin textureIt is.
Cross-linked Hyaluronic Acid Preparation Usage

Yayoi Clinic's hyaluronic acid injections use different cross-linked formulations depending on the injection site and effect. Hyaluronic acid isThe more cross-links, the harder and longer the duration tends to beThere are
ここでは5つの架橋ヒアルロン酸製剤の注入部位や効果、持続期間をご紹介します。
■Voluma XC
Injection sites are temples, cheeks, face line and chin. The effect of volume enhancement isLasts about 18-34 monthsIt has a relatively long duration among the five formulations.
■Borax XC
It is mainly injected into the face line and chin. It is used for contouring and lasts forAbout 18 monthsOf the five, this is the hardest formulation with more cross-linking.
■BOLIFT XC
It can be injected into the laugh lines and around the mouth to improve wrinkles. Duration.About 12 to 18 monthsIt is.
■Volvera XC
It is suitable for injection into the entire face, under the eyes and lips. The effect is to improve wrinkles, depressions, and increase volume.About 12 monthsSustained.
■Bolite XC
Injection sites include the entire face and neck. It improves skin texture and lasts for a long time.4 to 9 months。5つの中で一番やわらかく、持続期間が短い製剤です。
Treatment with non-cross-linked hyaluronic acid and hybrid hyaluronic acid

ヤヨイクリニックでは非架橋ヒアルロン酸に加え、ハイブリッドヒアルロン酸を使用する施術も取り扱っています。
まず、肌の水分保持や肌質改善に適した非架橋ヒアルロン酸製剤を用いる施術を3種類ご紹介します。
■Snechos
SUNECOS is an injection procedure that uses a formulation of six amino acids and non-cross-linked hyaluronic acid that provides firmness. The soft, non-cross-linked hyaluronic acid is the reason for this,Can be injected into thin and fine skin areas such as wrinkles around the eyes。自然な仕上がりで、ハリや弾力を感じる肌が目指せます。
■Jubeluk
JUVELUX approaches acne scars and pores with polylactic acid and non-cross-linked hyaluronic acid, which stimulate collagen production.Duration is relatively long, absorbed in the skin over 1-2 yearsされます。気になる部位を集中的に治療したり、注入量をカスタマイズしたりできるのも特徴です。
■Purreal
Plurial suitable for rosacea (rosacea) and redness problems. Mainly polynucleotides extracted from salmon and trout, which are high in antioxidants,Injection of a drug containing non-cross-linked hyaluronic acid and mannitolです。肌のコラーゲン生成を促し、しなやかな肌が目指せるでしょう。
次に、ハイブリッドヒアルロン酸製剤を用いた施術を2つご紹介します。ハイブリッドヒアルロン酸は、異なる分子量のヒアルロン酸を特殊加工で配合しています。
■Profilo
PROFILO is a formulation containing two types of hyaluronic acid with different molecular sizes. It can be injected into the neck and back of the hands,Approaches fat cells and other cells that form the foundation of the skin。ハリや弾力が感じられる、ふっくらとした肌へ導きます。
■Hydro
Hydro is a combination of three types of hyaluronic acid. Unlike volumizing and contouring procedures, HydroInjection supports collagen production in the skinします。年を重ねた顔や首のハリ感向上が期待できる施術です。
For hyaluronic acid injections, visit YAYOI CLINIC
非架橋ヒアルロン酸と架橋ヒアルロン酸の違いと、それぞれの製剤を使った注入施術の特徴をご紹介しました。肌質改善やハリ感アップなら非架橋ヒアルロン酸、輪郭形成やボリュームアップなら架橋ヒアルロン酸が適しています。ヒアルロン酸注入の際は、ご自身のお悩みに合った製剤・施術を選択しましょう。
広島の美容皮膚科・美容内科・美容外科・アートメイク YAYOI CLINIC(ヤヨイクリニック)では、お肌、お体、お顔のお悩み別に治療法をご紹介しています。
皆さまにより良い選択肢をご提案できますよう一人ひとりのお肌の状態を見極め、治療期間やご予算、ダウンタイムの許容範囲などご希望に合わせた治療方針を立案していく考えです。
お悩みのある方は、まずはカウンセリングにお越しください。
【施術の内容】ヒアルロン酸
【施術回数の目安】
Hyaluronic acid: per treatment
Hyaluronidase: 1-2 times
*The number of treatments for each of these varies from person to person.
【費用】
ヒアルロン酸:1本 ¥79,800(+施術料 ¥22,000)※使用する本数には個人差があります。
ヒアルロニダーゼ:
・自院:1回 ¥33,000
・他院:1回 ¥55,000
【副作用・リスク】
Very rare side effects of hyaluronic acid have been reported, including transient or irreversible blindness, induced stroke, as well as nodules, beaded nodules, allergic reactions, granulomas, herpes, lack of or decreased correction, misalignment, necrosis, numbness, pain, tumors, infection, angioedema, discoloration and hematomas.
Side effects of hyaluronidase have been reported to include needle marks, internal bleeding, and allergic reactions.
If you notice any of these symptoms or any other abnormalities, please consult your doctor as soon as possible.
【使用機器について】
Fillers and hyaluronidase injections include drugs not approved in Japan and treatments that differ from their approved regulatory use.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
Information on safety, etc. in other countries
-Juviderm Vista® series: approved in Japan for "correction of moderate to severe wrinkles and furrows on the face
-Hyaluronidase: Approved by MFDS, Korea
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】スネコス
【施術回数の目安】2週間に1回×3~4回(1クール)※治療内容によっても異なります。
【費用】¥128,000〜¥175,800※部位・回数によって料金は異なります。
【副作用・リスク】出血、赤み、腫れ、圧痛、疼痛、痒み、軽度/中程度のアザ、軽度の浮腫、内出血など
【使用機器について】
Snekos treatment includes the use of unapproved drugs or medical devices in Japan.
The medicines and medical devices used for treatment were imported by private individuals based on the judgment of the doctors at our clinic. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
The following certifications have been obtained
-The special ratio of amino acids in the drug has been patented internationally by an Italian development company.
-CE Mark Class III (European safety standard conformity approval)
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】ジュベルック
【施術回数の目安】
Fine wrinkles: 1-2 times per month
Skin texture improvement: about twice per month
Acne scars: about 3 times per month
*Depends on the condition of the skin.
【費用】1回¥55,000~149,800
【副作用・リスク】
Redness, swelling, and swelling at the injection site
【使用機器について】
JUVELEC's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
U.S. Food and Drug Administration (FDA)
Ministry of Food and Drug Safety of Korea (MFDS)
CE Medicines in Europe
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】プルリアル
【施術回数の目安】2~3週間に1回(1クール:3回程度)※治療間隔は肌状態によって異なります。
【費用】¥71,000~204,000円※部位・回数によって料金は異なります。
【副作用・リスク】処置後の出血、浮腫、腫れのない紅斑、赤み、腫れ、かゆみ、血腫、圧痛など
【使用機器について】
Pluryal treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from MD Skin Solutions, Inc. under the judgment of our doctors.
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
-All products are CE certified in Europe.
About the Adverse Reactions Relief System for Drugs
-In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief Program.
【施術の内容】プロファイロ
【施術回数の目安】
Initial: 2 times at 1 month intervals
After the second time: once every six months
*The number of treatments depends on the skin age.
【費用】¥82,000~¥158,400※回数によって料金は異なります。
【副作用・リスク】注入部位の痛み、炎症、赤み、かゆみ、腫れ、内出血、体質によるアレルギー反応など
【使用機器について】
Profibro's treatment includes procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Serious risks and side effects may not be evident.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.
【施術の内容】ハイドロ
【施術回数の目安】2週間ごとに3~4回
【費用】¥71,000~204,000円※部位・回数によって料金は異なります。
【副作用・リスク】
Tingling, itching, redness, and heat may occur for about 2 days after treatment.
Swelling may remain for 1-2 days and internal bleeding for about 7 days, but usually resolves spontaneously.
Depending on the individual and the injection site, the puffiness may remain for 1-3 days after treatment. It will settle naturally as the drug is diffused.
【使用機器について】
Hydro treatments include procedures using domestically unapproved drugs or medical devices.
The medicines and medical devices used for treatment were imported from Japan under the judgment of our doctors. Please refer to the following for information on medicines and other items of concern for personal importation.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
There are no other domestically approved drugs with the same ingredients or performance.
Information on safety, etc. in other countries
Obtained European CE Mark[p1].
Serious risks, side effects, etc. may not have been identified.
About the Adverse Reactions Relief System for Drugs
In the unlikely event of serious side effects, the drug is not covered by the government's Adverse Drug Reactions Relief System.

